Memphis is a city in Shelby County, Tennessee, of which it is the county seat. As of 2006, the city of Memphis had an estimated population of 680,768, making it the largest city in the state of Tennessee, the second largest in the southeastern region (only to Jacksonville, Florida), and the 17th largest in the United States [1]. The greater Memphis metropolitan area (including the adjacent areas of Mississippi and Arkansas) has a population of 1,260,581. This makes Memphis the second largest metropolitan area in Tennessee, surpassed only by metropolitan Nashville. Even though Memphis is the state's largest city, it is the youngest of Tennessee's four major cities (traditionally including Knoxville and Chattanooga as well as Nashville). Memphis is on the Lower Chickasaw Bluff above the Mississippi River in the western portion of the state at the mouth of the Wolf River.